Application of (2'R,5'R)-2-[(2',5'-Dimethylpyrrolidin-1-yl)-methyl]pyridine and (2'R,5'R)-2-[(2',5'-Diphenylpyrrolidin-1-yl)methyl]pyridine to the Palladium-Catalyzed Allylic Alkylation.
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منابع مشابه
Efficient palladium-catalyzed asymmetric allylic alkylation of ketones and aldehydes.
Palladium-catalyzed asymmetric allylic alkylation of ketones, via enamines generated in situ as nucleophiles, were carried out smoothly with chiral metallocene-based P,N-ligands. Under the same conditions, however, reactions of aldehydes could hardly be observed. Subsequently, this obstacle was resolved by using chiral metallocene-based P,P-ligands. Both ketones and aldehydes afforded excellent...
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The search for new ligands in asymmetric catalysis is a field of continuing interest. To facilitate practical applications, new ligands should be easy to prepare from simple and easily available starting materials. In this context, the use of chiral nitrogen compounds bearing an organochalcogen moiety and their metal complexes have gained increased importance in the field of asymmetric catalysi...
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The first general method for the enantioselective construction of all-carbon quaternary centers on cyclopentanones by enantioselective palladium-catalyzed decarboxylative allylic alkylation is described. Employing the electronically modified (S)-(p-CF3)3-t-BuPHOX ligand, α-quaternary cyclopentanones were isolated in yields up to >99% with ee's up to 94%. Additionally, in order to facilitate lar...
متن کاملPalladium-catalyzed decarboxylative allylic alkylation of diastereomeric β-ketoesters.
The palladium-catalyzed decarboxylative allylic alkylation of diastereomeric β-ketoesters derived from 4-tert-butylcyclohexanone is described. These experiments were performed to elucidate our understanding of stereoablative enantioconvergent catalysis. A detailed analysis of the product distribution, including stereochemical outcome of the products, is included. These studies also reveal an in...
متن کاملPalladium catalyzed allylic C-H alkylation: a mechanistic perspective.
The atom-efficiency of one of the most widely used catalytic reactions for forging C-C bonds, the Tsuji-Trost reaction, is limited by the need of preoxidized reagents. This limitation can be overcome by utilization of the recently discovered palladium-catalyzed C-H activation, the allylic C-H alkylation reaction which is the topic of the current review. Particular emphasis is put on current mec...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1998
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.52-0961